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Document ID (ISN)75051
CIS number 00-741
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Sathiakumar N., Delzell E., Hovinga M., Macaluso M., Julian J.A., Larson R., Cole P., Muir D.C.F.
Title Mortality from cancer and other causes of death among synthetic rubber workers
Bibliographic information Apr. 1998, Vol.55, No.4, p.230-235. 22 ref.
Abstract A retrospective follow-up study was conducted among 15,649 men employed for at least one year at any of eight North American styrene-butadiene rubber plants. Analyses used standardized mortality ratios (SMRs) to compare styrene-butadiene rubber workers' cause-specific mortalities (1943-91) with those of the United States and Ontario general populations. On average, there were 25 years of follow-up per subject. The SMR was 87 for all causes of death combined and 93 for all cancers. There was an excess of leukaemia among hourly workers. For causes of death other than leukaemia, SMRs were close to or below the null value of 100. Results by work area (process group) were unremarkable for non-Hodgkin's lymphoma, multiple myeloma and stomach cancer. Maintenance workers had a slight increase in deaths from lung cancer, and certain subgroups of workers had more than the expected number of deaths from cancer of the large intestine and the larynx. This study found an excess of leukaemia that is likely to be due to exposure to butadiene or to butadiene plus other chemicals. Deaths from non-Hodgkin's-lymphoma, multiple myeloma and stomach cancer did not seem to be related to occupational exposure.
Descriptors (primary) butadiene-styrene rubber; synthetic rubber industry; cancer; mortality
Descriptors (secondary) leukaemia; styrene; statistical evaluation; long-term study; dose-response relationship; butadiene
Document type D - Periodical articles
Country / State or ProvinceCanada; USA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Industries and occupations
Browse category(ies) Chemical industry
Plastics industry