| Document ID (ISN) | 75014 |
| CIS number |
00-790 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Padungtod C., Niu T., Wang Z., Savitz D.A., Christiani D.C., Ryan L.M., Xu X. |
| Title |
Paraoxonase polymorphism and its effect on male reproductive outcomes among Chinese pesticide factory workers |
| Bibliographic information |
Sep. 1999, Vol.36, No.3, p.379-387. 29 ref. |
| Abstract |
The effects of the human paraoxonase gene (PON1) genotypes on male reproductive outcomes and its interaction with exposure to organophosphate pesticides were examined in 60 Chinese pesticide-factory workers and 89 textile-factory workers who were unexposed to pesticides. The respective allele frequencies of Arg192 and Gln192 were 0.62 and 0.38. Pesticide exposure among 36 exposed subjects and 12 unexposed subjects, regardless of gender, was assessed by personal measurement of pesticide residues over an entire 8-hr shift and measurement of urinary p-nitrophenol level over a 24-hr period. Semen and hormone data collected from male subjects were analysed. Exposed Arg192 homo/heterozygotes had significantly lower sperm count and lower percentage of sperm with normal morphology than the reference group. Both unexposed Gln192 homozygotes and exposed Arg192 homo/heterozygotes showed significantly lower sperm concentrations than the reference group. In addition, exposed Arg192 homo/heterozygotes had significantly higher serum LH levels than the reference group. |
| Descriptors (primary) |
antifertility effects; exposure tests; pesticide production |
| Descriptors (secondary) |
parathion; China; enzymes; hormones; tamaron; exposure evaluation; urinary metabolites; individual susceptibility; determination in blood; spermatogenic disturbances |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Genetic factors in reaction to exposures
Biological monitoring
Antifertility and prenatal effects
|
