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Document ID (ISN)74938
CIS number 00-782
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Wang X., Yano E.
Title Pulmonary dysfunction in silica-exposed workers: A relationship to radiographic signs of silicosis and emphysema
Bibliographic information Aug. 1999, Vol.36, No.2, p.299-306. 29 ref.
Abstract To compare the contribution of silicosis and emphysema with pulmonary dysfunction, radiographic signs of silicosis and emphysema in workers at a Chinese refractory plant were analysed. Radiographic hyperinflation was detected in 9% of the workers without silicosis and in 33% of the workers with silicosis. Silicosis was significantly associated with hyperinfiation after adjusting for exposure duration, age and smoking. Respiratory symptoms were more frequent in the more severe cases of silicosis. Silicosis was significantly associated with decreases in the parameters of pulmonary function, but the significance disappeared when the hyperinflation term was added to the models. Radiographic hyperinflation was strongly associated with decreases in FEV1 and FEV1/FVC while relevant factors were controlled. Comparison between workers with and without hyperinflation showed that the former had significantly lower pulmonary function values. Emphysema associated with silicosis is likely to be responsible for pulmonary obstruction and decreased diffusing capacity occurring in silica-exposed workers.
Descriptors (primary) silica; silicosis; respiratory diseases; emphysema
Descriptors (secondary) diffusion capacity; respirable dust; chest radiography; spirometry; respiratory function tests
Document type D - Periodical articles
Country / State or ProvinceChina; Japan
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Pneumoconioses
Diseases of the respiratory system (except for pneumoconiosis & similar)