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Document ID (ISN)74932
CIS number 00-723
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Padungtod C., Hassold T.J., Millie E., Ryan L.M., Savitz D.A., Christiani D.C., Xu X.
Title Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method
Bibliographic information Aug. 1999, Vol.36, No.2, p.230-238. Illus. 32 ref.
Abstract Cases from a pesticide-manufacturing plant in Anhui, China, and controls from a nearby textile factory were recruited. Pesticide workers were exposed to ethyl parathion or methamidophos at a median level of 0.02mg/m3. Semen was collected from each subject. Scoring was based on three-color fluorescence in situ hybridization (FISH). Median semen parameters for exposed (and unexposed) men were: abstinence period, 3 days (4 days); sperm concentration, 52.8 x 106/mL (53.1 x 106/mL); proportion of sperm with normal motility, 50.5% (61.3%); and proportion of sperm with normal morphology, 59% (61.5%). The crude proportion of all aneuploidy combined was 0.30% and 0.19% for sperm from exposed and unexposed men, respectively. Poisson regression yielded significantly different crude risks of aneuploidy - 3.03 and 1.94 per 1,000 sperm from exposed and unexposed men, respectively. Regression coefficients remained statistically significant after adjustment for inter-technician variability giving a rate ratio of 1.51. It is concluded that occupational exposure to organophosphate pesticides moderately increases the prevalence of sperm aneuploidy.
Descriptors (primary) China; organophosphorus compounds; pesticide production; chromosome changes; spermatogenic disturbances
Descriptors (secondary) parathion; antifertility effects; case-control study; tamaron; statistical evaluation; detection by fluorescence; genetic effects
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Industries and occupations
Browse category(ies) Diseases of the reproductive system
Chemical industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects