|Document ID (ISN)||74932|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Padungtod C., Hassold T.J., Millie E., Ryan L.M., Savitz D.A., Christiani D.C., Xu X.
||Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method
||Aug. 1999, Vol.36, No.2, p.230-238. Illus. 32 ref.
||Cases from a pesticide-manufacturing plant in Anhui, China, and controls from a nearby textile factory were recruited. Pesticide workers were exposed to ethyl parathion or methamidophos at a median level of 0.02mg/m3. Semen was collected from each subject. Scoring was based on three-color fluorescence in situ hybridization (FISH). Median semen parameters for exposed (and unexposed) men were: abstinence period, 3 days (4 days); sperm concentration, 52.8 x 106/mL (53.1 x 106/mL); proportion of sperm with normal motility, 50.5% (61.3%); and proportion of sperm with normal morphology, 59% (61.5%). The crude proportion of all aneuploidy combined was 0.30% and 0.19% for sperm from exposed and unexposed men, respectively. Poisson regression yielded significantly different crude risks of aneuploidy - 3.03 and 1.94 per 1,000 sperm from exposed and unexposed men, respectively. Regression coefficients remained statistically significant after adjustment for inter-technician variability giving a rate ratio of 1.51. It is concluded that occupational exposure to organophosphate pesticides moderately increases the prevalence of sperm aneuploidy.
||China; organophosphorus compounds; pesticide production; chromosome changes; spermatogenic disturbances
||parathion; antifertility effects; case-control study; tamaron; statistical evaluation; detection by fluorescence; genetic effects
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
||Industries and occupations
||Diseases of the reproductive system
Genetic factors in reaction to exposures
Antifertility and prenatal effects