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Document ID (ISN)74901
CIS number 00-709
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Elliott P., Arnold R., Cockings S., Eaton N., Jńrup L., Jones J., Quinn M., Rosato M., Thornton I., Toledano M., Tristan E., Wakefield J.
Title Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium
Bibliographic information Feb. 2000, Vol.57, No.2, p.94-97. 22 ref.
Abstract The English village of Shipham has very high concentrations of cadmium in the soil. A previous cohort study of residents from 1939 to 1979 showed overall mortality below that expected, but a 40% excess of mortality from stroke. This study extends the follow up of the cohort to 1997. Standardized mortality and incidence ratios were estimated with regional reference rates. Comparisons were made with the nearby village of Hutton. All-cause mortality was lower than expected in both villages, although there was excess cancer incidence in both Shipham and Hutton. There was an excess of mortality from hypertension, cerebrovascular disease, and nephritis and nephrosis, of borderline significance, in Shipham. In a geographical study, all-cause mortality in Shipham was also lower than expected. There was an excess in genitourinary cancers in both Shipham and Hutton. In conclusion, no clear evidence of health effects from possible exposure to cadmium in Shipham was found despite the extremely high concentrations of cadmium in the soil.
Descriptors (primary) cerebral embolism; cadmium; cancer; mortality
Descriptors (secondary) hypertension; United Kingdom; nephritis; frequency rates; cohort study; long-term study; nephrosis
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the nervous system
Cadmium and compounds
Inorganic substances