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CISDOC database

Document ID (ISN)74738
CIS number 00-487
ISBN(s) 0-7176-2437-4
Year 1999
Convention or series no. HSE Contract Research Report CRR 216/1999
Author(s) Cullen R.T., Tran C.L., Buchanan D., Davis J.M.G., Jones A.D., Searl A., Donaldson K.
Health and Safety Executive
Title Investigations into pulmonary effects of low toxicity dusts - Parts I and II
Bibliographic information HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 1999. xii, 280p. Illus. Bibl.ref. Price: GBP 70.00.
Abstract The aim of this study was firstly to assess the relative toxicities of a panel of nine low-toxicity respirable dusts in in-vitro and in-vivo assays in rats. Lung instillation and inhalation tests provoked inflammatory response and particulate accumulation in the lungs. Data show differences in pulmonary responses to inhalation of the dusts and in the distribution of macrophage. In a second part, two dusts (titanium dioxide and barium sulfate) were used to evaluate the dose-response relationship between lung burden and specific biologically adverse effects (retardation of alveolar clearance and pulmonary inflammation), to validate a predictive mathematical model and to estimate the NOAEL level.
Descriptors (primary) inhalation; pneumotoxic effects; respirable dust; lung diseases
Descriptors (secondary) barium sulfate; histological effects; macrophages; United Kingdom; titanium dioxide; alveolar clearance; animal experiments; dose-response relationship; report
Document type E - Books, reports, proceedings
Country / State or ProvinceUnited Kingdom
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)