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CISDOC database
| Document ID (ISN) | 74684 |
| CIS number |
00-471 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1999 |
| Convention or series no. |
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| Author(s) |
Calvert G.M., Sweeney M.H., Deddens J., Wall D.K. |
| Title |
Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin |
| Bibliographic information |
Apr. 1999, Vol.56, No.4, p.270-276. 21 ref. |
| Abstract |
A cross-sectional study of workers employed >15 years earlier in the manufacturing of 2,4,5-trichlorophenol or one of its derivatives at two United States chemical plants was conducted. The control group consisted of people with no occupational exposure to phenoxy herbicides and were recruited from the neighbourhoods where the workers lived. A total of 281 workers and 260 unexposed controls participated. Overall, the prevalence of diabetes mellitus was not significantly different between the workers and controls. Also, there was not a significant positive trend between prevalence of diabetes and increasing serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentration. However, diabetes was found in six of ten workers. After excluding subjects being treated for diabetes, workers in the group with the highest extrapolated half-life TCDD concentrations had a significantly increased adjusted mean serum glucose concentration compared with controls. Workers were also found to have a significantly higher adjusted mean free thyroxine index than the controls, especially among workers in the group with the highest extrapolated half-life TCDD concentrations. However, no evidence was found for the relationship between exposure to TCDD and an increased risk of thyroid disease. |
| Descriptors (primary) |
diabetes mellitus; blood sugar level; thyroid function; tetrachlorodibenzodioxin |
| Descriptors (secondary) |
USA; determination in blood; cross-sectional study |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Heterocyclic compounds
Metabolic diseases
Blood diseases
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