|Document ID (ISN)||74507|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Tomei F., Giuntoli P., Biagi M., Baccolo T.P., Tomao E., Rosati M.V.
||Liver damage among shoe repairers
||Nov. 1999, Vol.36, No.5, p.541-547. Illus. 32 ref.
||33 shoe repairers working in supermarkets using glues containing potentially hepatotoxic solvents were identified and compared to a control group of 61 non-exposed workers. Participants completed a questionnaire designed to identify risk factors and non-occupational confounding factors for hepatotoxicity. Common laboratory tests were conducted to check whether they were useful markers of hepatotoxicity caused by exposure to solvents, and to select tests for screening campaigns. Exposed workers had a higher prevalence of elevated mean alanine aminotransferase (ALT), aspartate aminotransferase (AST), conjugated bilirubin, and alkaline phosphatase (AP) and a ratio of ALT to AST greater than 1, with a mean of 1.5. Findings suggest that there is the possibility of liver involvement among even asymptomatic shoe repairers, and that periodic liver screening may be useful; furthermore use of these tests (especially the ratio of ALT to AST) for craftsmen who are exposed to solvents is advisable even when environmental monitoring indicates levels below the threshold limit values.
||hepatotoxic effects; shoemakers; exposure tests; organic solvents
||hepatic damage; transaminases; determination in blood; case-control study; exposure evaluation
||D - Periodical articles
|Country / State or Province||Italy|
|Broad subject area(s)
||Occupational medicine, epidemiology
||Footwear, leather and fur industry