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Document ID (ISN)74507
CIS number 00-408
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Tomei F., Giuntoli P., Biagi M., Baccolo T.P., Tomao E., Rosati M.V.
Title Liver damage among shoe repairers
Bibliographic information Nov. 1999, Vol.36, No.5, p.541-547. Illus. 32 ref.
Abstract 33 shoe repairers working in supermarkets using glues containing potentially hepatotoxic solvents were identified and compared to a control group of 61 non-exposed workers. Participants completed a questionnaire designed to identify risk factors and non-occupational confounding factors for hepatotoxicity. Common laboratory tests were conducted to check whether they were useful markers of hepatotoxicity caused by exposure to solvents, and to select tests for screening campaigns. Exposed workers had a higher prevalence of elevated mean alanine aminotransferase (ALT), aspartate aminotransferase (AST), conjugated bilirubin, and alkaline phosphatase (AP) and a ratio of ALT to AST greater than 1, with a mean of 1.5. Findings suggest that there is the possibility of liver involvement among even asymptomatic shoe repairers, and that periodic liver screening may be useful; furthermore use of these tests (especially the ratio of ALT to AST) for craftsmen who are exposed to solvents is advisable even when environmental monitoring indicates levels below the threshold limit values.
Descriptors (primary) hepatotoxic effects; shoemakers; exposure tests; organic solvents
Descriptors (secondary) hepatic damage; transaminases; determination in blood; case-control study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Footwear, leather and fur industry
Biological monitoring