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Document ID (ISN)74371
CIS number 00-181
ISSN - Serial title 1219-1221 - Central European Journal of Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Indulski J.A., Lutz W., Krajewska B.
Title Serum and urine p53 protein in bladder cancer patients and in workers occupationally exposed to genotoxic and mutagenic dyes
Bibliographic information 1999, Vol.5, No.1, p.17-25. Illus. 23 ref.
Abstract Blood serum and urine protein concentrations in patients with urinary bladder cancer and in people occupationally exposed to dusts containing genotoxic or mutagenic dyes were determined using an enzyme-linked immunosorbent assay. Increased concentrations ranging from 30 to 289pg/ml of protein p53 in blood serum were found in 10 of 21 patients with bladder cancer. Elevated urine p53 protein concentrations ranging from 27 to 496pg/ml were found in 13 of the 21 patients with bladder cancer. These concentrations did not show any relationship with tumor stage. In the group of 29 healthy persons occupationally exposed to genotoxic and mutagenic dyes, p53 protein was detected in more than 40% of the test subjects, while in the control group of healthy persons who were not occupationally exposed to the carcinogenic agents, the corresponding figure was only 20%. The p53 protein levels were considerably lower than for the persons with bladder cancer. Urine protein p53 can serve as a useful occupational and environmental carcinogens.
Descriptors (primary) mutagens; dyes; exposure tests; dyestuff industry; bladder tumour
Descriptors (secondary) smoking; serum protein changes; determination in urine; blood monitoring; urine monitoring; determination in blood
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Biological monitoring
Diseases of the kidney and the urinary system