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Document ID (ISN)74366
CIS number 00-119
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1998
Convention or series no.
Author(s) Weiderpass E., Partanen T., Kaaks R., Vainio H., Porta M., Kauppinen T., Ojajńrvi A., Boffetta P., Malats N.
Title Occurrence, trends and environmental etiology of pancreatic cancer
Bibliographic information June 1998, Vol.24, No.3, p.165-174. 215 ref.
Abstract This review summarizes data on the occurrence, the trends, and the life-style, environmental, occupational and genetic determinants of pancreatic cancer. Epidemiologic evidence implicates tobacco smoking as one cause. The evidence regarding alcohol consumption is inconsistent. Although both positive and inconclusive findings are encountered, the bulk of the evidence on coffee consumption is negative. Fat intake is linked with obesity and diabetes mellitus, which are risk factors for pancreatic cancer. Fruit and vegetable consumption appears to be protective. No occupational or environmental agent has been confirmed to increase the risk, but epidemiologic evidence is inconsistent. Little is known about the role of genetic polymorphisms of metabolic enzymes in pancreas carcinogenesis, and evidence associating mutations with life-style factors is still scant and inconsistent.
Descriptors (primary) epidemiology; risk factors; tumour of the pancreas
Descriptors (secondary) non-occupational factors; literature survey; genetic abnormalities; statistical trends; diet; enzymes; aetiology; alcoholism; smoking; metabolic process
Document type D - Periodical articles
Country / State or ProvinceSpain; Finland; France; Sweden
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Endocrine diseases
Alcohol and drug abuse