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CISDOC database

Document ID (ISN)74237
CIS number 00-173
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Bernstein D.I., Jolly A.
Title Current diagnostic methods for diisocyanate induced occupational asthma
Bibliographic information Oct. 1999, Vol.36, No.4, p.459-468. Illus. 34 ref.
Abstract Accurate diagnosis of diisocyanate asthma requires a systematic approach that combines information obtained from the occupational history, immunologic tests and physiologic studies. Recommended methods for evaluation of diisocyanate asthma are similar to approaches for other causative agents. Serologic assays of specific IgE are specific but insensitive diagnostic markers of diisocyanate asthma. If possible, workers should be evaluated, while at work, in order to demonstrate work-related changes in lung function associated with diisocyanate exposures. Specific bronchoprovocation challenge testing with diisocyanates, is reserved for situations where the diagnosis cannot be confirmed at work. Such tests can be performed safely but should be conducted exclusively at specialized centres by experienced personnel. Published diagnostic guidelines for occupational asthma are directly applicable to the evaluation of diisocyanate asthma.
Descriptors (primary) isocyanates; diagnosis; asthma
Descriptors (secondary) literature survey; anamnesis; immunology; inhalation tests; allergic reactivity; respiratory function tests; hypersensitivity; occupational medicine; skin tests
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds