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Document ID (ISN)74233
CIS number 00-172
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Marsh G.M., Gula M.J., Youk A.O., Schall L.C.
Title Mortality among chemical plant workers exposed to acrylonitrile and other substances
Bibliographic information Oct. 1999, Vol.36, No.4, p.423-436. 52 ref.
Abstract The association between exposure to acrylonitrile (AN) and cancer mortality was studied for a cohort of workers from a chemical plant. Worker exposures were estimated quantitatively for AN and qualitatively for nitrogen products. No statistically significant excess mortality risks were observed among the total cohort for cancers of the stomach, lung, breast, prostate, brain, and hematopoietic system. A statistically significant bladder cancer excess was observed, based on four deaths (SMR = 7.01) among workers not exposed to AN. Among 518 AN-exposed workers, an excess of lung cancer was observed based on external (SMR = 1.32) and internal (RR = 1.98) comparisons. With the possible exception of lung cancer, little evidence was found that exposure to AN at levels experienced by these workers is associated with an increased risk of death from any cause including the implicated cancer sites.
Descriptors (primary) chemical industry; cancer; mortality; acrylonitrile
Descriptors (secondary) USA; nitrogen and compounds; lung cancer; dose-response relationship; exposure evaluation; cohort study; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Cyano compounds
Chemical industry