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Document ID (ISN)74197
CIS number 00-166
ISSN - Serial title 0140-6736 - Lancet
Year 1999
Convention or series no.
Author(s) Compston J.E., Vedi S., Stephen A.B., Bord S., Lyons A.R., Hodges S.J., Scammell B.E.
Title Reduced bone formation after exposure to organophosphates
Bibliographic information Nov. 1999, Vol.354, No.9192, p.1791-1792. 5 ref.
Abstract In an earlier study, agricultural workers with chronic exposure to organophosphates (OPs) through sheep-dipping showed lower bone mineral density compared to normal values. In this study, bone biopsy samples were obtained from 24 agricultural workers seeking litigation for ill-health caused by chronic exposure to OPs, and compared with 24 controls, both groups having participated in the earlier study. Histomorphometric analysis showed significantly lower bone formation at tissue and cellular level than in healthy controls. The presence of acetylcholinesterase in the bone matrix provides a possible explanation for the OP-induced effects in bone.
Descriptors (primary) livestock rearing; bone mineral density; agricultural operations; insecticides; organophosphorus compounds
Descriptors (secondary) acetylcholinesterase; biopsy; long-term exposure; case-control study
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Livestock rearing
Agricultural chemicals