|Document ID (ISN)||74018|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Brüning T., Chronz C., Thier R., Havelka J., Ko Y., Bolt H.M.
||Occurrence of urinary tract tumours in miners highly exposed to dinitrotoluene
||Mar. 1999, Vol.41, No.3, p.144-149. 33 ref.
||Higher than expected incidences of urothelial and renal cell tumours were found in a group of underground copper miners with high exposures to explosives containing dinitrotoluene. Categorization of the renal cell tumour cases by exposure revealed no dose-dependency concerning explosives and was similar to that of a representative group of formerly dinitrotoluene-exposed workers, whereas the urothelial tumour cases were predominantly confined to the high-exposure categories. These results along with results of genotyping indicate the possibility of human carcinogenicity of dinitrotoluene with regard to urothelium as the target tissue. Topics: bladder tumour; dinitrotoluene; copper mining; dose-response relationship; epidemiologic study; explosives; genito-urinary system diseases; latency; length of exposure; neoplasms; renal cancer; skin absorption.
||explosives; copper mining; bladder tumour; dinitrotoluene
||genito-urinary system diseases; latency; skin absorption; neoplasms; epidemiologic study; length of exposure; dose-response relationship; renal cancer
||D - Periodical articles
|Country / State or Province||Germany|
||Mines and quarries
|Broad subject area(s)
||Mining and quarrying
Diseases of the kidney and the urinary system
Aliphatic nitro compounds