|Document ID (ISN)||74007|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Roos F., Renier A., Ettlinger J., Iwatsubo Y., Letourneux M., Haguenoer J.M., Jaurand M.C., Pairon J.C.
||Assessment of potential damage to DNA in urine of coke oven workers: An assay of unscheduled DNA synthesis
||Dec. 1997, Vol.54, No.12, p.854-860. Illus. 42 ref.
||In a study of 60 coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and 40 controls, the high concentrations of urinary 1-hydroxypyrene (1OHP) observed in the coke oven workers reflected recent exposure to PAHs and were in agreement with assessment of exposure by job. No significant difference was found between coke oven workers and controls in the DNA repair levels of rat cells treated with urine samples. However, the rat cell repair capacity decreased with increasing 1OHP concentration in the exposed population. While exposure to PAHs was not associated with a clear cut modification of the urinary excretion of DNA damaging factors in this test, impairment of some repair mechanisms by urinary constituents is suspected. Topics: aromatic hydrocarbons; coke ovens; determination in urine; DNA; exposure evaluation; genetic effects; job-exposure relation; polycyclic hydrocarbons; urinary metabolites.
||aromatic hydrocarbons; genetic effects; polycyclic hydrocarbons; coke ovens
||DNA; exposure evaluation; determination in urine; job-exposure relation; urinary metabolites
||D - Periodical articles
|Country / State or Province||France|
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures