ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)73935
CIS number 99-1940
ISSN - Serial title 0731-3810 - Journal of Toxicology - Clinical Toxicology
Year 1999
Convention or series no.
Author(s) Barceloux D.G.
Title Copper
Bibliographic information 1999, Vol.37, No.2, p.217-230. Illus. 118 ref.
Abstract Chronic copper toxicity is rare and primarily affects the liver. Wilson's disease and Indian childhood cirrhosis are examples of severe chronic liver disease that results from genetic predisposition to hepatic accumulation of copper. Copper sulfate is a gastric irritant that produces erosion of the lining of the gastrointestinal tract. Gastrointestinal symptoms occur at whole blood concentrations near 3mg Cu/L. Chelating agents (CaNa2EDTA, BAL) are recommended in severe poisoning, but there are little pharmacokinetic data to evaluate the effectiveness of these agents. Topics: acute toxicity; animal experiments; antidote treatment; biliary excretion; carcinogenic effects; copper; copper sulfate; chelating agents; chronic toxicity; copper and compounds; determination in blood; determination in urine; dose-response relationship; electrical industry; gastric disorders; health hazards; hepatic diseases; irritants; literature survey; medical treatment; metabolic process; toxicology; urinary excretion.
Descriptors (primary) copper and compounds; health hazards; toxicology
Descriptors (secondary) literature survey; determination in urine; acute toxicity; metabolic process; copper; chelating agents; urinary excretion; gastric disorders; hepatic diseases; biliary excretion; antidote treatment; animal experiments; chronic toxicity; electrical industry; dose-response relationship; carcinogenic effects; determination in blood; medical treatment; copper sulfate; irritants
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Copper and compounds
Inorganic substances