|Document ID (ISN)||73935|
|ISSN - Serial title
||0731-3810 - Journal of Toxicology - Clinical Toxicology
|Convention or series no.
||1999, Vol.37, No.2, p.217-230. Illus. 118 ref.
||Chronic copper toxicity is rare and primarily affects the liver. Wilson's disease and Indian childhood cirrhosis are examples of severe chronic liver disease that results from genetic predisposition to hepatic accumulation of copper. Copper sulfate is a gastric irritant that produces erosion of the lining of the gastrointestinal tract. Gastrointestinal symptoms occur at whole blood concentrations near 3mg Cu/L. Chelating agents (CaNa2EDTA, BAL) are recommended in severe poisoning, but there are little pharmacokinetic data to evaluate the effectiveness of these agents. Topics: acute toxicity; animal experiments; antidote treatment; biliary excretion; carcinogenic effects; copper; copper sulfate; chelating agents; chronic toxicity; copper and compounds; determination in blood; determination in urine; dose-response relationship; electrical industry; gastric disorders; health hazards; hepatic diseases; irritants; literature survey; medical treatment; metabolic process; toxicology; urinary excretion.
||copper and compounds; health hazards; toxicology
||literature survey; determination in urine; acute toxicity; metabolic process; copper; chelating agents; urinary excretion; gastric disorders; hepatic diseases; biliary excretion; antidote treatment; animal experiments; chronic toxicity; electrical industry; dose-response relationship; carcinogenic effects; determination in blood; medical treatment; copper sulfate; irritants
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)
||Copper and compounds