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Document ID (ISN)73918
CIS number 99-1962
ISSN - Serial title 0019-8366 - Industrial Health
Year 1999
Convention or series no.
Author(s) Kyono H., Serita F., Toya T., Kubota H., Arito H., Takahashi M., Maruyama R., Homma K., Ohta H., Yamauchi Y., Nakakita M., Seki Y., Ishihara Y., Kagawa J.
Title A new model rat with acute bronchiolitis and its application to research on the toxicology of inhaled particulate matter
Bibliographic information Jan. 1999, Vol.37, No.1, p.47-54. Illus. 20 ref.
Abstract An attempt was made to establish a useful animal model that simulates human sensitivity to inhaled particulate matter (PM). A new rat model of acute bronchiolitis (Br) was developed by exposing animals to aerosols containing nickel. To assess the sensitivity of the Br rats to inhaled particles, two kinds of PM of respirable size were tested with doses similar to or a little higher to the recommended threshold limit values (TLVs) for the working environment in Japan. Pathological changes in the lungs and clearance of particles in exposed Br rats were compared to those in normal control or Br rats kept in clean air. Delayed recovery from pre-existing lesions or exacerbated inflammation, and reductions in deposition and clearance rate of inhaled particles with the progress of lesions were observed in Br rats. Results suggest that Br rats are more susceptible to inhaled particles than control rats. Therefore, particulate matter at concentrations lower than the TLVs for Japan, which have no harmful effects on normal lungs, may not always be safe in the case of pre-existing lung inflammation. Topics: animal experiments; bronchiolitis; vanadium pentoxide; titanium dioxide; nickel(II) chloride; inflammations; light microscopy; lung deposition; respirable dust; toxic effects.
Descriptors (primary) toxic effects; animal experiments; respirable dust; bronchiolitis
Descriptors (secondary) lung deposition; inflammations; vanadium pentoxide; nickel(II) chloride; titanium dioxide; light microscopy
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Diseases of the respiratory system (except for pneumoconiosis & similar)