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Document ID (ISN)73906
CIS number 99-1959
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Boogaard P.J., Rocchi P.S.J., van Sittert N.J.
Title Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: Correlations between airborne exposure and adduct levels
Bibliographic information May 1999, Vol.72, No.3, p.142-150. Illus. 37 ref.
Abstract To establish correlations between airborne concentrations of ethylene oxide (EO) and propylene oxide (PO) and their haemoglobin (Hb) adducts in petrochemical workers, external occupational exposure to EO and PO was assessed by personal air monitoring (PAM), and internal exposure to EO and PO was assessed by determination of N-(2-hydroxyethyl)valine (HOEtVal) and N-(3-hydroxypropyl)valine (HOPrVal) in blood samples. In a first study, PAM was applied once a month at random over a period of four months. Blood samples for Hb-adduct determination were collected at the end of this period. No significant correlation was found between PAM and Hb-adduct data. In two following studies, PAM was applied to the operators during the entire shift on every working day. Blood samples were collected before and immediately after the study period. Significant correlations were found between the increment in the concentration of HOEtVal and HOPrVal and the total exposure to EO and PO respectively. Time-integrated exposure to EO or PO can be readily and reliably assessed from the concentration of HOEtVal or HOPrVal in a small blood sample. Topics: ethylene oxide; propylene oxide; description of technique; determination in air; determination in blood; dose-response relationship; exposure tests; haemoglobin monitoring; length of exposure; personal sampling.
Descriptors (primary) ethylene oxide; haemoglobin monitoring; exposure tests; propylene oxide
Descriptors (secondary) personal sampling; length of exposure; description of technique; determination in air; determination in blood; dose-response relationship
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Ethylene oxide