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CISDOC database

Document ID (ISN)73905
CIS number 99-1958
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Kolstad H.A., Bonde J.P., Spano M., Giwercman A., Zschiesche W., Kaae D., Larsen S.B., Roeleveld N.
Title Change in semen quality and sperm chromatin structure following occupational styrene exposure
Bibliographic information May 1999, Vol.72, No.3, p.135-141. 29 ref.
Abstract Semen samples were collected from 23 reinforced plastics workers at the time of employment and after six months of styrene exposure and from 21 nonexposed farmers. Intraindividual changes in conventional semen parameters and sperm-DNA denaturation patterns were related to the internal dose of styrene exposure measured by postshift urinary mandelic acid. A significant decline in sperm density was seen during styrene exposure from 63.5 to 46.0 million sperm/ml, whereas no decline was seen in nonexposed subjects. Total sperm count was almost halved from an initial value of 175 million sperm/ejaculate. No relationship was apparent when the sperm parameters were related to internal levels of exposure. A small exposure-response relationship was shown for DNA-denaturation patterns. A declining sperm count following styrene exposure is suggested, although the findings of the internal and external comparisons are inconsistent. This may be due to the high intraindividual variability of semen parameters, the limited study size and a weak internal exposure gradient. Topics: styrene; mandelic acid; case-control study; determination in urine; DNA; exposure evaluation; genetic effects; individual susceptibility; plastics industry; reinforced plastics; spermatogenic disturbances.
Descriptors (primary) styrene; reinforced plastics; plastics industry; genetic effects; spermatogenic disturbances
Descriptors (secondary) DNA; mandelic acid; determination in urine; case-control study; individual susceptibility; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany; Denmark; Italy; Netherlands
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the reproductive system
Antifertility and prenatal effects
Aromatic hydrocarbons
Chemical industry
Plastics industry
Genetic factors in reaction to exposures