|Document ID (ISN)||73876|
|ISSN - Serial title
||0105-1873 - Contact Dermatitis
|Convention or series no.
||Karlberg A.T., Basketter D., Goossens A., Lepoittevin J.P.
||Regulatory classification of substances oxidized to skin sensitizers on exposure to air
||Apr. 1999, Vol.40, No.4, p.183-188. 32 ref.
||When a specific chemical is classified as a skin sensitizer, this implies that the compound is stable throughout its lifetime. However, some skin sensitizing oxidation/degradation products are formed by air exposure of substances with very low allergenic activity. In regulatory classification work on skin sensitizers, the intrinsic susceptibility of a chemical to air oxidation should be taken into consideration. Examples of natural terpenoid materials are given, but the concept of allergens formed by air oxidation can apply to other materials widely used in industrial products. If a positive classification is made for a substance with a known chemical structure, a note should indicate that the primary chemical structure of the notified substance is not a skin sensitizer, but that some of its oxidation products are. Complex mixtures which inevitably contain sensitizing oxidation products should be classified as skin sensitizing. Topics: allergens; d-limonene; colophony; classification systems; European Communities; labelling; legislation; literature survey; oxidation; photochemical decomposition; sensitization dermatitis; sensitization; skin allergies.
||allergens; skin allergies; sensitization; oxidation; classification systems
||literature survey; sensitization dermatitis; European Communities; legislation; colophony; photochemical decomposition; labelling; d-limonene
||D - Periodical articles
|Country / State or Province||Belgium; France; United Kingdom; Sweden|
||Toxic and dangerous substances
|Broad subject area(s)