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Document ID (ISN)73875
CIS number 99-1929
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 1999
Convention or series no.
Author(s) Basketter D., Flyvholm M.A., MennÚ T.
Title Classification criteria for skin-sensitizing chemicals: A commentary
Bibliographic information Apr. 1999, Vol.40, No.4, p.175-182. 35 ref.
Abstract A formalized, standardized and effective mechanism for the identification of substances which possess significant skin sensitization potential is a necessary step in limiting the incidence of allergic contact dermatitis. Strategies to achieve such hazard identification are unified throughout the European Union and have also been publicised by the World Health Organization. Global harmonization of these and other approaches is being driven by the Organization for Economic Cooperation and Development. The benefits and limitations of these classification systems are reviewed. A common element of all the systems is that they seek to distinguish important contact allergens from chemicals which are infrequent sensitizers. The European criteria are legal requirements in the EU member states and formal classification as a skin sensitizer leads to mandatory labelling. The most notable omission from current and proposed classification criteria is the relative potency of a classified skin sensitizer and the exposure dose, necessary for proper risk assessment and management measures to be implemented. Topics: allergens; classification systems; European Communities; labelling; legislation; literature survey; OECD; sensitization dermatitis; sensitization; skin allergies; standardization; USA; WHO.
Descriptors (primary) allergens; sensitization; classification systems; skin allergies
Descriptors (secondary) literature survey; sensitization dermatitis; USA; WHO; legislation; OECD; labelling; standardization; European Communities
Document type D - Periodical articles
Country / State or ProvinceDenmark; United Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Allergies
Skin diseases