ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)73874
CIS number 99-1928
ISSN - Serial title 0098-7484 - Journal of the American Medical Association
Year 1999
Convention or series no.
Author(s) Khattak S., K-Moghtader G., McMartin K., Barrera M., Kennedy D., Koren G.
Title Pregnancy outcome following gestational exposure to organic solvents - A prospective controlled study
Bibliographic information Mar. 1999, Vol.281, No.12, p.1106-1109. 19 ref.
Abstract 125 pregnant women who were exposed occupationally to organic solvents and seen during the first trimester between 1987 and 1996 were matched to a pregnant woman who was exposed to a nonteratogenic agent for age, gravidity, and smoking and drinking status. Significantly more major malformations occurred among foetuses of women exposed to organic solvents than of controls. Twelve malformations occurred among the 75 women who had symptoms temporally associated with exposure, while none occurred among 43 asymptomatic exposed women. More of the exposed women had previous miscarriages while working with organic solvents than did controls. However, exposed women who had a previous miscarriage had rates of major malformation that were similar to exposed women who had had no miscarriage. Occupational exposure to organic solvents during pregnancy is associated with an increased risk of major foetal malformations. This risk appears to be increased among women who report symptoms associated with organic solvent exposure. Women's exposure to organic solvents should be minimized during pregnancy. Topics: abortion; case-control study; embryotoxic effects; expectant mothers; exposure evaluation; organic solvents; teratogenic effects; teratogens.
Descriptors (primary) teratogens; expectant mothers; teratogenic effects; organic solvents
Descriptors (secondary) embryotoxic effects; case-control study; exposure evaluation; abortion
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects