|Document ID (ISN)||73874|
|ISSN - Serial title
||0098-7484 - Journal of the American Medical Association
|Convention or series no.
||Khattak S., K-Moghtader G., McMartin K., Barrera M., Kennedy D., Koren G.
||Pregnancy outcome following gestational exposure to organic solvents - A prospective controlled study
||Mar. 1999, Vol.281, No.12, p.1106-1109. 19 ref.
||125 pregnant women who were exposed occupationally to organic solvents and seen during the first trimester between 1987 and 1996 were matched to a pregnant woman who was exposed to a nonteratogenic agent for age, gravidity, and smoking and drinking status. Significantly more major malformations occurred among foetuses of women exposed to organic solvents than of controls. Twelve malformations occurred among the 75 women who had symptoms temporally associated with exposure, while none occurred among 43 asymptomatic exposed women. More of the exposed women had previous miscarriages while working with organic solvents than did controls. However, exposed women who had a previous miscarriage had rates of major malformation that were similar to exposed women who had had no miscarriage. Occupational exposure to organic solvents during pregnancy is associated with an increased risk of major foetal malformations. This risk appears to be increased among women who report symptoms associated with organic solvent exposure. Women's exposure to organic solvents should be minimized during pregnancy. Topics: abortion; case-control study; embryotoxic effects; expectant mothers; exposure evaluation; organic solvents; teratogenic effects; teratogens.
||teratogens; expectant mothers; teratogenic effects; organic solvents
||embryotoxic effects; case-control study; exposure evaluation; abortion
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures
Antifertility and prenatal effects