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Document ID (ISN)73556
CIS number 99-1591
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Irsigler G.B., Visser P.J., Spangenberg P.A.L.
Title Asthma and chemical bronchitis in vanadium plant workers
Bibliographic information Apr. 1999, Vol.35, No.4, p.366-374. Illus. 37 ref.
Abstract The cause of cough and breathlessness in vanadium plant workers was examined after variable periods of exposure. Twelve of 40 subjects had bronchial hyperreactivity (BHR), and these were compared to 12 age-matched companion subjects whose BHR was normal. In ten, BHR was diagnosed by histamine inhalation, and in six of these the abnormality was severe. A further two had BHR by exercise challenge. After removal from exposure, 9 of the 12 subjects returned for follow-up 5 to 23 months later. BHR was worse in one, still present although less severe in five, and was no longer found in one subject. Baseline spirometry measurements were normal in seven subjects and only mildly impaired in the remaining five of the 12 subjects with BHR. The study provides strong supporting evidence that inhaled V2O5 induces BHR and asthma in subjects previously free of lung disease; the abnormality may persist for up to 23 months following exposure; routine spirometry will not detect affected subjects. Topics: allergic reactivity; allergy tests; asthma; vanadium pentoxide; determination in urine; exposure evaluation; hypersensitivity; inhalation tests; irritants; maximal expiratory flow; mining industry; respiratory function tests.
Descriptors (primary) asthma; allergic reactivity; mining industry; vanadium pentoxide
Descriptors (secondary) irritants; maximal expiratory flow; exposure evaluation; determination in urine; inhalation tests; respiratory function tests; hypersensitivity; allergy tests
Document type D - Periodical articles
Country / State or ProvinceSouth Africa
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Mining and quarrying
Inorganic substances