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Document ID (ISN)73520
CIS number 99-1559
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Perico A., Cassinelli C., Brugnone F., Bavazzano P., Perbellini L.
Title Biological monitoring of occupational exposure to cyclohexane by urinary 1,2- and 1,4-cyclohexanediol determination
Bibliographic information Mar. 1999, Vol.72, No.2, p.115-120. Illus. 18 ref.
Abstract Individual exposure to cyclohexane was evaluated in 156 workers employed in shoe and leather factories by measurement of 1,2-cyclohexanediol (1,2-DIOL) and 1,4-DIOL in urine during the working week. Individual exposure to cyclohexane ranged from 7 to 617mg/m3. Urinary concentrations of 1,2-DIOL were 3.1, 7.6, 13.2 and 6.3mg/g creatinine on Monday (pre- and post-shift), Thursday (post-shift) and Friday (pre-shift), respectively. Corresponding values recorded for 1,4- DIOL were 2.8, 5.1, 7.8 and 3.7mg/g creatinine. A significant correlation was found between environmental exposure to cyclohexane and post-shift urinary 1,2-DIOL and 1,4-DIOL on Monday. Data for Thursday and Friday showed only a poor correlation to exposure. Both metabolites have a urinary half-life of close to 18h and accumulate during the week. Comparison between data obtained from a PBPK model and those found in workers suggests that 1,2-DIOL and 1,4-DIOL are suitable for the biological monitoring of industrial exposure to cyclohexane. Topics: adhesives; cyclohexane; determination in air; exposure evaluation; exposure tests; leather goods industry; shift work; shoe industry; urinary metabolites; urine monitoring.
Descriptors (primary) cyclohexane; urinary metabolites; shoe industry; exposure tests; leather goods industry
Descriptors (secondary) shift work; adhesives; urine monitoring; determination in air; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Aliphatic and alicyclic hydrocarbons
Footwear, leather and fur industry