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CISDOC database
| Document ID (ISN) | 73520 |
| CIS number |
99-1559 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1999 |
| Convention or series no. |
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| Author(s) |
Perico A., Cassinelli C., Brugnone F., Bavazzano P., Perbellini L. |
| Title |
Biological monitoring of occupational exposure to cyclohexane by urinary 1,2- and 1,4-cyclohexanediol determination |
| Bibliographic information |
Mar. 1999, Vol.72, No.2, p.115-120. Illus. 18 ref. |
| Abstract |
Individual exposure to cyclohexane was evaluated in 156 workers employed in shoe and leather factories by measurement of 1,2-cyclohexanediol (1,2-DIOL) and 1,4-DIOL in urine during the working week. Individual exposure to cyclohexane ranged from 7 to 617mg/m3. Urinary concentrations of 1,2-DIOL were 3.1, 7.6, 13.2 and 6.3mg/g creatinine on Monday (pre- and post-shift), Thursday (post-shift) and Friday (pre-shift), respectively. Corresponding values recorded for 1,4- DIOL were 2.8, 5.1, 7.8 and 3.7mg/g creatinine. A significant correlation was found between environmental exposure to cyclohexane and post-shift urinary 1,2-DIOL and 1,4-DIOL on Monday. Data for Thursday and Friday showed only a poor correlation to exposure. Both metabolites have a urinary half-life of close to 18h and accumulate during the week. Comparison between data obtained from a PBPK model and those found in workers suggests that 1,2-DIOL and 1,4-DIOL are suitable for the biological monitoring of industrial exposure to cyclohexane. Topics: adhesives; cyclohexane; determination in air; exposure evaluation; exposure tests; leather goods industry; shift work; shoe industry; urinary metabolites; urine monitoring. |
| Descriptors (primary) |
cyclohexane; urinary metabolites; shoe industry; exposure tests; leather goods industry |
| Descriptors (secondary) |
shift work; adhesives; urine monitoring; determination in air; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Footwear, leather and fur industry
Biological monitoring
Aliphatic and alicyclic hydrocarbons
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