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Document ID (ISN)73516
CIS number 99-1583
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Panemangalore M., Dowla H.A., Byers M.E.
Title Occupational exposure to agricultural chemicals: Effect on the activities of some enzymes in the blood of farm workers
Bibliographic information Mar. 1999, Vol.72, No.2, p.84-88. 27 ref.
Abstract Eight volunteers who were working on a small tobacco farm were monitored over a period of two years along with a comparable urban unexposed group. Activity of δ-aminolevulinic acid dehydratase (ALAD) was depressed by 30% after 1 day and there was no further decrease in ALAD activity after 30 days of field work. Superoxide dismutase (SOD) activity, in contrast, declined by 29% and 50% after 1 day and 30 days, respectively, as compared with 0-day activity and that of the urban control, which was similar to 0-day activity. Plasma cholinesterase activity declined by 19% after both 1 and 30 days of exposure/field work. The activities of all three enzymes were restored to urban control or pre-exposure levels during post-exposure. Plasma cadmium levels were high in the samples taken after 30 days as compared with the pre-exposure levels. Respiratory nicotine exposure was highest after 30 days of field work. This preliminary study suggests that erythrocyte SOD is a sensitive indicator of exposure to agricultural chemicals in tobacco field workers. Topics: agricultural chemicals; ALAD; blood monitoring; maleic acid hydrazide; orthene; nicotine; cadmium; cholinesterase monitoring; cholinesterase; determination in blood; enzyme activity; exposure evaluation; metabolism of blood constituents; pesticides; smoking; superoxide dismutase; tobacco farming.
Descriptors (primary) agricultural chemicals; metabolism of blood constituents; tobacco farming; pesticides; enzyme activity
Descriptors (secondary) cholinesterase monitoring; orthene; ALAD; nicotine; cholinesterase; maleic acid hydrazide; smoking; exposure evaluation; determination in blood; blood monitoring; cadmium; superoxide dismutase
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Agricultural chemicals