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Document ID (ISN)73396
CIS number 99-1275
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Larsson B.M., Larsson K., Malmberg P., Mňrtensson L., Palmberg L.
Title Airway responses in naive subjects to exposure in poultry houses: Comparison between cage rearing system and alternative rearing system for laying hens
Bibliographic information Feb. 1999, Vol.35, No.2, p.142-149. Illus. 25 ref.
Abstract 34 previously non-exposed subjects were exposed for 3h in confined poultry houses in three groups: one in a building with a cage rearing system and two in buildings with a cage-less system with either young hens and fresh bedding material or with older hens and old bedding material. Inhalable dust levels were approximately 4mg/m3 in the buildings with the cage-less system and 2mg/m3 in the building with cage rearing system; the endotoxin concentration was approximately 100ng/m3 in both systems. Bronchial responsiveness to methacholine increased approximately fivefold in all groups following exposure. The concentration of the proinflammatory cytokine interleukin-6 increased in nasal lavage fluid and in peripheral blood as a result of exposure. The number of leukocytes in peripheral blood increased only in the groups exposed among loose laying hens. Results indicate that among previously non-exposed subjects, that 3h exposure in confined buildings for egg production induces an acute inflammatory reaction in the upper airways and increased bronchial responsiveness. Topics: airborne dust; bacterial toxins; bronchial diseases; confined spaces; epidemiologic study; exposure evaluation; inflammations; interleukins; organic dust; poultry farming; pulmonary function; upper respiratory diseases.
Descriptors (primary) upper respiratory diseases; poultry farming; confined spaces; organic dust
Descriptors (secondary) airborne dust; interleukins; bacterial toxins; epidemiologic study; inflammations; pulmonary function; exposure evaluation; bronchial diseases
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Livestock rearing
Confined spaces