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Document ID (ISN)73395
CIS number 99-1265
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Lundqvist G., Flodin U., Axelson O.
Title A case-control study of fatty liver disease and organic solvent exposure
Bibliographic information Feb. 1999, Vol.35, No.2, p.132-136. 26 ref.
Abstract Thirty male cases of fatty liver disease (FLD) with available biopsy records were compared to 120 randomly selected controls. Questionnaire information was obtained about job titles and specific occupational exposures; exposure level categories were then assessed blindly for both cases and controls. Medical records were examined to determine possible confounding and/or interacting effects from alcohol, the use of drugs, and other diseases. Moderately intense and mixed solvent exposure for more than 1 year within the last 15 years prior to diagnosis resulted in an age-adjusted Mantel-Haenszel odds ratio of 4.3; for intense exposure, the odds ratio was 7.7. Confounding from alcohol, use of drugs, other diseases, and overweight could be ruled out with reasonable confidence. This study indicates that occupational exposure to organic solvents may play a role in the development of FLD, as indicated earlier in case reports and in one small case-control study. Topics: adiposis hepatica; alcoholism; case-control study; exposure evaluation; hepatotoxic effects; length of exposure; obesity; organic solvents.
Descriptors (primary) hepatotoxic effects; adiposis hepatica; organic solvents
Descriptors (secondary) alcoholism; obesity; length of exposure; case-control study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Alcohol and drug abuse
Liver diseases