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Document ID (ISN)73356
CIS number 99-1254
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Straif K., Weiland S., Werner B., Wienke A., Keil U.
Title Elevated mortality from nonalcohol-related chronic liver disease among female rubber workers: Is it associated with exposure to nitrosamines?
Bibliographic information Mar. 1999, Vol.35, No.3, p.264-271. Illus. 54 ref.
Abstract In a long-term mortality study of 2,875 female rubber workers in a plant producing tires or technical rubber goods, the excess mortality from cirrhosis of the liver was most pronounced for nonalcohol-related cirrhosis of the liver. Mortality from alcohol-related cirrhosis of the liver and from other alcohol-related diseases was not significantly elevated. All cases of nonalcohol-related cirrhosis had worked in production of technical rubber goods and risks increased with earlier years of hire and with longer duration of employment in this work area. Although results should be interpreted with caution, they suggest that the observed excess deaths from cirrhosis of the liver are associated with occupational risk factors. Exposure to nitrosamines may be a plausible risk factor. Topics: alcoholism; cirrhosis; cohort study; dose-response relationship; exposure evaluation; hepatic diseases; mortality; nitroso amines; risk factors; rubber industry; women.
Descriptors (primary) rubber industry; nitroso amines; women; hepatic diseases; mortality
Descriptors (secondary) alcoholism; cirrhosis; dose-response relationship; cohort study; risk factors; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Liver diseases
Rubber industry
Alcohol and drug abuse