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Document ID (ISN)73322
CIS number 99-1232
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Griffin P., Mason H., Heywood K, Cocker J.
Title Oral and dermal absorption of chlorpyrifos: A human volunteer study
Bibliographic information Jan. 1999, Vol.56, No.1, p.10-13. Illus. 9 ref.
Abstract An oral dose of chlorpyrifos was readily absorbed and almost all of the dose was recovered as urinary dialkylphosphate metabolites. Chlorpyrifos was also absorbed through the skin. Excretion was delayed compared with the oral dose. Only a small proportion of the applied dose was recovered during the course of the experiment. The best time to collect urine samples for biological monitoring after dermal exposure is before the shift the next day. The amounts of chlorpyrifos used did not depress acetyl cholinesterase activity but could be readily detected as urinary dialkylphosphate metabolites indicating that the urinary assay is a more sensitive indicator of exposure. Topics: acetylcholinesterase; chlorpyrifos; determination in blood; determination in urine; exposure evaluation; ingestion; insecticides; metabolic process; skin absorption; urinary metabolites.
Descriptors (primary) chlorpyrifos; urinary metabolites; exposure evaluation; insecticides
Descriptors (secondary) acetylcholinesterase; metabolic process; determination in urine; skin absorption; determination in blood; ingestion
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Esters and salts
Agricultural chemicals