|Document ID (ISN)||73322|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Griffin P., Mason H., Heywood K, Cocker J.
||Oral and dermal absorption of chlorpyrifos: A human volunteer study
||Jan. 1999, Vol.56, No.1, p.10-13. Illus. 9 ref.
||An oral dose of chlorpyrifos was readily absorbed and almost all of the dose was recovered as urinary dialkylphosphate metabolites. Chlorpyrifos was also absorbed through the skin. Excretion was delayed compared with the oral dose. Only a small proportion of the applied dose was recovered during the course of the experiment. The best time to collect urine samples for biological monitoring after dermal exposure is before the shift the next day. The amounts of chlorpyrifos used did not depress acetyl cholinesterase activity but could be readily detected as urinary dialkylphosphate metabolites indicating that the urinary assay is a more sensitive indicator of exposure. Topics: acetylcholinesterase; chlorpyrifos; determination in blood; determination in urine; exposure evaluation; ingestion; insecticides; metabolic process; skin absorption; urinary metabolites.
||chlorpyrifos; urinary metabolites; exposure evaluation; insecticides
||acetylcholinesterase; metabolic process; determination in urine; skin absorption; determination in blood; ingestion
||D - Periodical articles
|Country / State or Province||United Kingdom|
||Toxic and dangerous substances
|Broad subject area(s)
Esters and salts