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CISDOC database

Document ID (ISN)73148
CIS number 99-1245
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1997
Convention or series no.
Author(s) Jńrup L., Persson B., Elinder C.G.
Title Blood cadmium as an indicator of dose in a long-term follow-up of workers previously exposed to cadmium
Bibliographic information Feb. 1997, Vol.23, No.1, p.31-36. Illus. 36 ref.
Abstract The tubular function of 46 workers initially examined in 1984 and heavily exposed to cadmium from 1955 to 1978 was investigated. Although cadmium exposure ceased in 1978, 40% of the workers showed signs of tubular dysfunction both in 1984 and 1993. The current cadmium in blood level (B-Cd) was the best dose indicator. Dose-response relationships were found for B-Cd and various tubular markers. Urinary excretion of protein HC (α1-microglobulin) appeared to be the most sensitive, as well as an early, indicator of cadmium-induced tubular dysfunction. A history of renal stones was significantly more common for workers with high B-Cd levels. Topics: cadmium; determination in blood; determination in urine; dose-response relationship; exposure evaluation; exposure tests; long-term exposure; long-term study; nephrotoxic effects; proteinuria; renal dysfunction; soldering and brazing; urinary lithiasis; urine monitoring.
Descriptors (primary) renal dysfunction; cadmium; exposure tests; urinary lithiasis
Descriptors (secondary) proteinuria; soldering and brazing; exposure evaluation; long-term study; determination in urine; dose-response relationship; nephrotoxic effects; determination in blood; urine monitoring; long-term exposure
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Biological monitoring
Diseases of the kidney and the urinary system
Cadmium and compounds