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Document ID (ISN)73008
CIS number 99-926
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1999
Convention or series no.
Author(s) Fox J., Anderson H., Moen T., Gruetzmacher G., Hanrahan L., Fink J.
Title Metal working fluid-associated hypersensivity pneumonitis: An outbreak investigation and case-control study
Bibliographic information Jan. 1999, Vol.35, No.1, p.58-67. Illus. 32 ref.
Abstract Occupational exposure to bacterial or fungal antigens has been associated with hypersensivity pneumonitis (HP), an immunologically-mediated pulmonary disease. 34 employees working in machining and assembly areas of an engine manufacturing plant were clinically diagnosed with HP. Of these, 20 employees met an epidemiologic case definition. In a case-control study, no exposure variables, including duration and intensity of metal working fluid (MWF) exposure, were statistically associated with an increased risk of disease. Neither cases nor controls demonstrated precipitin reactivity against unused samples of the seven MWF and two biocides used in the plant. HP cases had a significantly higher prevalence of positive precipitin reactions to used oil-soluble and synthetic MWFs. Reactivity to used but not unused MWF suggests a biocontaminant, probably bacteria or fungi, is the causative antigen in the development of HP in this setting. Topics: allergens; antigens; bacteria; biocides; case-control study; cutting fluids; extrinsic allergic alveolitis; fungi; motor vehicle industry; pulmonary function; serological reactions; serum precipitins; used oils.
Descriptors (primary) extrinsic allergic alveolitis; motor vehicle industry; cutting fluids
Descriptors (secondary) allergens; antigens; biocides; bacteria; serum precipitins; used oils; pulmonary function; case-control study; serological reactions; fungi
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Motor vehicle manufacturing industry
Pneumoconioses