| Document ID (ISN) | 72913 |
| CIS number |
99-883 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Wrbitzky R. |
| Title |
Liver function in workers exposed to N,N-dimethylformamide during the production of synthetic textiles |
| Bibliographic information |
Jan. 1999, Vol.72, No.1, p.19-25. Illus. 49 ref. |
| Abstract |
The hepatotoxic effects of N,N-dimethylformamide (DMF) and the combination effects of DMF exposure and ethyl alcohol consumption were investigated in 126 male employees of a synthetic fibres production factory. DMF concentrations in air ranged from < 0.1 to 37.9ppm. Concentrations of the DMF metabolite N-methylformamide (NMF) in urine were 0.05-22.0mg/L (preshift) and 0.9-100.0mg/L (postshift), corresponding to 0.02-44.6mg/g creatinine (preshift) and 0.4-62.3mg/g creatinine (postshift). The results indicate a statistically significant toxic influence of DMF on liver function. Alcohol has a synergistic effect. The effects of DMF and of alcohol are dose-dependent. Experience gained from former occupational health surveillance in DMF-exposed persons and from the present study show that there are individual differences in tolerance of interactions between DMF and ethyl alcohol. Further studies are necessary for the evaluation of these individual degrees of susceptibility. Topics: alcoholism; dimethylformamide; cross-sectional study; determination in urine; exposure evaluation; hepatotoxic effects; liver function tests; metabolic process; synergism; synthetic fibre industry. |
| Descriptors (primary) |
synthetic fibre industry; dimethylformamide; hepatotoxic effects |
| Descriptors (secondary) |
metabolic process; alcoholism; exposure evaluation; determination in urine; synergism; liver function tests; cross-sectional study |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Amides
Alcohol and drug abuse
|
