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CISDOC database

Document ID (ISN)72913
CIS number 99-883
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Wrbitzky R.
Title Liver function in workers exposed to N,N-dimethylformamide during the production of synthetic textiles
Bibliographic information Jan. 1999, Vol.72, No.1, p.19-25. Illus. 49 ref.
Abstract The hepatotoxic effects of N,N-dimethylformamide (DMF) and the combination effects of DMF exposure and ethyl alcohol consumption were investigated in 126 male employees of a synthetic fibres production factory. DMF concentrations in air ranged from < 0.1 to 37.9ppm. Concentrations of the DMF metabolite N-methylformamide (NMF) in urine were 0.05-22.0mg/L (preshift) and 0.9-100.0mg/L (postshift), corresponding to 0.02-44.6mg/g creatinine (preshift) and 0.4-62.3mg/g creatinine (postshift). The results indicate a statistically significant toxic influence of DMF on liver function. Alcohol has a synergistic effect. The effects of DMF and of alcohol are dose-dependent. Experience gained from former occupational health surveillance in DMF-exposed persons and from the present study show that there are individual differences in tolerance of interactions between DMF and ethyl alcohol. Further studies are necessary for the evaluation of these individual degrees of susceptibility. Topics: alcoholism; dimethylformamide; cross-sectional study; determination in urine; exposure evaluation; hepatotoxic effects; liver function tests; metabolic process; synergism; synthetic fibre industry.
Descriptors (primary) synthetic fibre industry; dimethylformamide; hepatotoxic effects
Descriptors (secondary) metabolic process; alcoholism; exposure evaluation; determination in urine; synergism; liver function tests; cross-sectional study
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Alcohol and drug abuse