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Document ID (ISN)72912
CIS number 99-882
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1999
Convention or series no.
Author(s) Yokota K., Johyama Y., Yamaguchi K., Takeshita T., Morimoto K.
Title Exposure-response relationships in rhinitis and conjunctivitis caused by methyltetrahydrophthalic anhydride
Bibliographic information Jan. 1999, Vol.72, No.1, p.14-18. 17 ref.
Abstract Workers from 2 condenser plants using epoxy resin with methyl tetrahydrophthalic anhydride (MTHPA) underwent a questionnaire survey and serology investigations. In all, 65% of workers studied in plant A and 66% in plant B had positive MTHPA-specific IgE. IgE-sensitized workers in each plant had significantly more eye and nasal complaints than did unsensitized workers, suggesting that there is an IgE-mediated mechanism in most of these symptoms. 15% of symptomatic workers in plant B often displayed work-related symptoms, as compared with 73% of the symptomatic workers in plant A. These results can be explained by the difference in MTHPA levels measured in the two plants. In plant B the minimum level of MTHPA that was associated with work-related symptoms was 15-22µg/m3, which was lower than the geometric mean levels detected in assembly and inspection lines in plant A. These levels suggest that MTHPA exposure at levels above 15µg/m3 should be avoided to prevent occupational allergic diseases. Topics: capacitors; methyl tetrahydrophthalic anhydride; conjunctivitis; dose-response relationship; immunoglobulin changes; immunoglobulins; limitation of exposure; rhinitis; threshold limit values.
Descriptors (primary) rhinitis; capacitors; dose-response relationship; conjunctivitis; methyl tetrahydrophthalic anhydride
Descriptors (secondary) threshold limit values; limitation of exposure; immunoglobulin changes; immunoglobulins
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the eye and vision damage
Diseases of the respiratory system (except for pneumoconiosis & similar)