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CISDOC database

Document ID (ISN)72879
CIS number 99-880
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1998
Convention or series no.
Author(s) Lai J.S., Kwo H.W., Liao F.C., Lien C.H.
Title Sister chromatid exchange induced by chromium compounds in human lymphocytes
Bibliographic information Nov. 1998, Vol.71, No.8, p.550-553. Illus. 16 ref.
Abstract In a study of chromium and nickel-chromium electroplating workers, blood and urine chromium concentrations were highest among chromium workers, next highest among nickel-chromium workers and lowest among a non-exposed control group. After adjustment for smoking, values of sister chromatid exchange (SCE)/cell followed a similar pattern. Among smokers with high levels of chromium exposure, a synergistic effect resulted: percentages of high-frequency cells were higher in this group than in any other. Analysis of SCE in lymphocytes is useful for the evaluation of the biological effects of environmental mutagens. Topics: analysis of chromosome aberrations; nickel; case-control study; chromium and compounds; chromosome changes; determination in blood; determination in urine; electroplating; genetic effects; length of exposure; lymphocytes; mutagens; smoking; synergism.
Descriptors (primary) lymphocytes; chromium and compounds; chromosome changes; electroplating
Descriptors (secondary) mutagens; nickel; smoking; case-control study; genetic effects; determination in urine; length of exposure; determination in blood; analysis of chromosome aberrations; chromium; synergism
Document type D - Periodical articles
Country / State or ProvinceTaiwan (China)
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Surface treatment
Inorganic substances
Genetic factors in reaction to exposures