ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)72841
CIS number 99-898
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Padungtod C., Lasley B.L., Christiani D.C., Ryan L.M., Xu X.
Title Reproductive hormone profile among pesticide factory workers
Bibliographic information Dec. 1998, Vol.40, No.12, p.1038-1047. Illus. 38 ref.
Abstract In a study of pesticide factory workers exposed to organophosphate pesticides, there was a negative correlation between urinary levels of follicle-stimulating hormone (FSH) and sperm count and between urinary FSH level and sperm concentration. Pesticide exposure alone was associated with serum level of luteinizing hormone (LH) but not with serum FSH or testosterone or with any urinary hormone levels. With adjustment for age, rotating shift work, cigarette smoking and alcohol consumption, exposure increased serum LH level; serum FSH level was slightly elevated and the serum testosterone level was decreased with increasing exposure. Age and rotating shift work appeared to act as confounders. It was concluded that organophosphate pesticides have a small effect on male reproductive hormones, suggestive of a secondary hormonal disturbance after testicular damage. Topics: antifertility effects; case-control study; determination in blood; determination in urine; exposure evaluation; hormone secretion; hormones; organophosphorus compounds; pesticide production; smoking; spermatogenic disturbances; testosterone.
Descriptors (primary) antifertility effects; pesticide production; hormone secretion; organophosphorus compounds
Descriptors (secondary) hormones; testosterone; smoking; determination in urine; exposure evaluation; case-control study; determination in blood; spermatogenic disturbances
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Chemical industry
Genetic factors in reaction to exposures