|Document ID (ISN)||72741|
|ISSN - Serial title
||1341-9145 - Journal of Occupational Health
|Convention or series no.
||Takeuchi Y., Ichihara G., Kamijima M.
||A review on toxicity of 2-bromopropane: Mainly on its reproductive toxicity
||July 1997, Vol.39, No.3, p.179-191. 43 ref.
||Risk asessment of 2-bromopropane based on recent epidemiologic and experimental animal data and the toxicity of structurally related bromopropanes. Conclusions: 2-bromopropane has demonstrated specific reproductive and haematopoietic toxicity in both sexes in humans and in experimental animals. This includes impaired spermatogenesis; impaired ovarian function, resulting in a disturbed oestrus cycle and loss of oocytes in females; and pancytopenia. It is also mutagenic in bacterial mutation assays. An occupational exposure limit of less than 10 ppm is recommended. Topics: 2-bromopropane; animal experiments; antifertility effects; determination in air; diseases of blood-forming organs; epidemiologic study; length of exposure; menstrual disorders; organic solvents; pancytopenia; spermatogenic disturbances.
||2-bromopropane; diseases of blood-forming organs; antifertility effects
||pancytopenia; organic solvents; spermatogenic disturbances; determination in air; epidemiologic study; animal experiments; length of exposure; menstrual disorders
||D - Periodical articles
|Country / State or Province||Japan|
||Toxic and dangerous substances
|Broad subject area(s)
Genetic factors in reaction to exposures
Antifertility and prenatal effects