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CISDOC database

Document ID (ISN)72741
CIS number 99-558
ISSN - Serial title 1341-9145 - Journal of Occupational Health
Year 1997
Convention or series no.
Author(s) Takeuchi Y., Ichihara G., Kamijima M.
Title A review on toxicity of 2-bromopropane: Mainly on its reproductive toxicity
Bibliographic information July 1997, Vol.39, No.3, p.179-191. 43 ref.
Abstract Risk asessment of 2-bromopropane based on recent epidemiologic and experimental animal data and the toxicity of structurally related bromopropanes. Conclusions: 2-bromopropane has demonstrated specific reproductive and haematopoietic toxicity in both sexes in humans and in experimental animals. This includes impaired spermatogenesis; impaired ovarian function, resulting in a disturbed oestrus cycle and loss of oocytes in females; and pancytopenia. It is also mutagenic in bacterial mutation assays. An occupational exposure limit of less than 10 ppm is recommended. Topics: 2-bromopropane; animal experiments; antifertility effects; determination in air; diseases of blood-forming organs; epidemiologic study; length of exposure; menstrual disorders; organic solvents; pancytopenia; spermatogenic disturbances.
Descriptors (primary) 2-bromopropane; diseases of blood-forming organs; antifertility effects
Descriptors (secondary) pancytopenia; organic solvents; spermatogenic disturbances; determination in air; epidemiologic study; animal experiments; length of exposure; menstrual disorders
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Halogenated hydrocarbons
Genetic factors in reaction to exposures
Antifertility and prenatal effects