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CISDOC database

Document ID (ISN)72737
CIS number 99-472
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1998
Convention or series no.
Author(s) Arndt V., Brenner H., Rothenbacher D., Zschenderlein B., Fraisse E., Fliedner T.M.
Title Elevated liver enzyme activity in construction workers: Prevalence and impact on early retirement and all-cause mortality
Bibliographic information Sep. 1998, Vol.71, No.6, p.405-412. 41 ref.
Abstract In a study of 8,043 male construction workers aged 25-64 years, the baseline prevalence of elevated activity levels of gamma-glutamyl transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) was 32%, 22% and 12% respectively. Factors most strongly related to elevated serum activity levels for all three enzymes were self-reported alcohol consumption, diabetes and hypertension. Body mass index was strongly associated with elevations in GGT and ALT but not in AST. Elevated levels of AST and GGT were strongly related to early retirement and all-cause mortality. Findings suggest that screening for elevated GGT and AST levels, which are a common finding among construction workers, may be a powerful tool for the identification of individuals at increased risk of early retirement and preterm mortality and may be helpful in targeting of prevention efforts. Topics: alcoholism; glutamic-pyruvic transaminase; glutamic-oxalacetic transaminase; gamma-glutamyl transpeptidase; cohort study; construction industry; enzyme activity; expertise; liver function tests; long-term study; mortality; smoking.
Descriptors (primary) mortality; construction industry; enzyme activity
Descriptors (secondary) glutamic-pyruvic transaminase; glutamic-oxalacetic transaminase; gamma-glutamyl transpeptidase; alcoholism; expertise; cohort study; long-term study; liver function tests; smoking
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Construction industry
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Blood diseases
Construction industry and civil engineering
Alcohol and drug abuse