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CISDOC database

Document ID (ISN)72465
CIS number 99-568
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Laintinen J., Liesivuori J., Savolainen H.
Title Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates
Bibliographic information July 1998, Vol.40, No.7, p.595-600. Illus. 27 ref.
Abstract In a study to evaluate the usefulness of urinary excretion of glycosaminoglycans (GAG) as biomarkers of early kidney effects in exposure to 2-alkoxyethanols and their acetates, GAG excretion was compared with effects on the activity of the urinary enzyme β-N-acetylglycosaminidase (NAG). The excretion rate of GAG was higher among women than men; it was lower among exposed subjects than among controls, and the level was decreased at the tested levels of exposure. The NAG activity was higher in most of the exposed groups than in the controls. Data indicated that an appropriate urinary limit value for ethoxyacetic acid was 30mmol/mol creatinine in postshift samples and that this value corresponded to an 8h exposure level of 2cm3/m3 2-ethoxyethylacetate. Urinary butoxyacetic acid excretion of 60mmol/mol creatinine corresponded to the inhalation exposure level of 5cm3/m3 2-butoxyethanol and its acetate in postshift samples. Topics: butoxyethanol; ethoxyethanol; 2-ethoxyethyl acetate; 2-butoxyethyl acetate; butoxyacetic acid; 2-ethoxyacetic acid; continuous monitoring; determination in urine; enzymological tests; exposure evaluation; limitation of exposure; mucopolysaccharides; nephrotoxic effects; renal function tests; sex-linked differences; urinary excretion; urinary metabolites; urine monitoring.
Descriptors (primary) ethoxyethanol; butoxyethanol; enzymological tests; determination in urine; nephrotoxic effects
Descriptors (secondary) 2-butoxyethyl acetate; butoxyacetic acid; 2-ethoxyacetic acid; 2-ethoxyethyl acetate; mucopolysaccharides; urinary excretion; urine monitoring; exposure evaluation; urinary metabolites; renal function tests; sex-linked differences; continuous monitoring; limitation of exposure
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Glycol ethers