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CISDOC database

Document ID (ISN)70197
CIS number 97-1973
ISSN - Serial title 0019-8366 - Industrial Health
Year 1997
Convention or series no.
Author(s) Bogadi-Šare A., et al.
Title Genotoxic effects in workers exposed to benzene: With special reference to exposure markers and confounding factors
Bibliographic information July 1997, Vol.35, No.3, p.367-373. 31 ref.
Abstract Cytogenetic tests were carried out on the lymphocytes of 49 female shoemakers exposed to benzene and toluene. Levels of benzene and toluene in the workers' blood and levels of phenol in urine were also measured. Chromosome aberration analysis revealed a significant increase in dicentric incidence in the exposed workers with respect to a control group. While significant correlation between cytogenetic test results and exposure biomarkers was not established, correlation between cytogenetic test results and data on confounding factors (age, alcohol consumption) was marked. The influence of confounding factors should be considered when estimating individual genotoxicity risk related to low level benzene exposure.
Descriptors (primary) benzene; toluene; shoemakers; genetic effects; exposure tests; organic solvents
Descriptors (secondary) confounding factors; determination in urine; analysis of chromosome aberrations; determination in blood
Document type D - Periodical articles
Country / State or ProvinceCroatia
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Biological monitoring
Aromatic hydrocarbons
Footwear, leather and fur industry
Genetic factors in reaction to exposures