| Document ID (ISN) | 70143 |
| CIS number |
97-1971 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
1997 |
| Convention or series no. |
|
| Author(s) |
Fine J.M., et al. |
| Title |
Metal fume fever: Characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value |
| Bibliographic information |
Aug. 1997, Vol.39, No.8, p.722-726. Illus. 20 ref. |
| Abstract |
In a study of the clinical effects of exposure to low concentrations of zinc oxide, 13 subjects were exposed to air or to 2.5 or 5mg/m3 of furnace-generated zinc oxide fume for 2h. Symptoms and temperature were recorded and blood samples were taken after exposure. The rise in oral temperature was greater after inhalation of zinc oxide than after air inhalation. Plasma levels of interleukin 6 (IL-6), a pyrogen, were significantly elevated after exposure to 5mg/m3 of zinc oxide. The predominant symptoms reported were myalgias, cough and fatigue. Inhalation of zinc oxide for 2h at the current threshold limit value of 5mg/m3 produces fever, symptoms and elevation in plasma IL-6 levels. |
| Descriptors (primary) |
metal fume fever; zinc oxide |
| Descriptors (secondary) |
interleukins; determination in blood; body temperature |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Inorganic substances
|
