ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)69830
CIS number 97-1589
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1996
Convention or series no.
Author(s) Osterman-Golkar S., Bond J.A.
Title Biomonitoring of 1,3-butadiene and related compounds
Bibliographic information Oct. 1996, Vol.104, Suppl.5, p.907-915. Illus. 85 ref.
Abstract Studies on the biomonitoring of butadiene and related compounds are reviewed. Sources of exposure to butadiene (carcinogenic in mice and rats) include cigarette smoke and emissions from butadiene production, storage, transport and use; the most likely route of uptake in inhalation. Biomonitoring is based on chemical analysis of butadiene in exhaled breath, levels of butadiene metabolites (epoxides) in blood and urine, or adducts of metabolites with DNA or blood proteins. Biomonitoring methods need to be developed for diepoxybutane and other reactive butadiene metabolites.
Descriptors (primary) carcinogens; exposure tests; biological effects; butadiene
Descriptors (secondary) literature survey; metabolic process; DNA; determination in urine; determination in blood; determination in exhaled air; toxic metabolites
Document type D - Periodical articles
Country / State or ProvinceSweden; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Aliphatic and alicyclic hydrocarbons