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Document ID (ISN)69674
CIS number 97-1575
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1997
Convention or series no.
Author(s) Dalene M., Skarping G., Lind P.
Title Workers exposed to thermal degradation products of TDI- and MDI-based polyurethane: Biomonitoring of 2,4-TDA, 2,6-TDA, and 4,4-MDA in hydrolyzed urine and plasma
Bibliographic information Aug. 1997, Vol.58, No.8, p.587-591. 19 ref.
Abstract Blood and urine samples were collected from 15 factory workers exposed to thermal degradation products of 4,4'-methylenediphenyl diisocyanate (MDI)-based polyurethane glue and to 2,4- and 2,6-toluene diisocyanate (TDI)-based flexible foam. Urine and plasma were analyzed after acidic hydrolysis, and the concentrations of the isocyanates' corresponding amines, 2,4-, 2,6-toluenediamine (TDA), and 4,4'-methylenedianiline (MDA) were determined. Peaks of 2,4-TDA, 2,6-TDA and 4,4'-MDA in urine varied during and between workdays. The individual variation in plasma concentration of these substances with time was small, but between individuals the variation was great. Results demonstrate the value of these biomarkers for assessing isocyanate exposure.
Descriptors (primary) isocyanates; exposure tests; 2,4-tolylene diisocyanate; 2,6-tolylene diisocyanate
Descriptors (secondary) 2,4-diaminotoluene; 2,6-diaminotoluene; determination in urine; determination in blood
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Isocyanates
Cyano compounds