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Document ID (ISN)69265
CIS number 97-963
ISBN(s) 91-7045-229-6
Year 1993
Convention or series no. Arbete och hälsa 1993:24
Author(s) Savolainen K.
Title Nordic Expert Group for Documentation of Occupational Exposure Limits. 108. Ethylenebisdithiocarbamates and ethylenethiourea
Original title Nordiska Expertgruppen för Gränsvärdesdokumentation. 108. Etylenbisditiokarbamater och etylentiourinämne [in Swedish]
Bibliographic information Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1993. 44p. 165 ref.
Abstract A critical survey of the literature relevant to the discussion of an occupational exposure limit for ethylenebisdithiocarbamate (EBDC) fungicides (maneb, mancozeb and zineb) and ethylenethiourea (ETU) is given. The critical effects of exposure to EBDCs are toxic effects on the thyroid gland, and their sensitizing, cross sensitizing and cross-reactivity properties. Mancozeb is also a possible carcinogen. The critical effects of ETU are directed towards the thyroid gland, where ETU induces thyroid hyperplasia and follicular carcinomas at low doses. The occupational exposure limits for EBDCs are based on their sensitizing properties, on their effects on the thyroid gland and their possible carcinogenic effects in rodents. The main emphasis in the occupational exposure limit for ETU is on its goitrogenic and thyroid carcinogenic properties. There is a need to emphasize the significance of biological monitoring, and to reduce exposure to EBDCs and ETU rather than develop more detailed occupational exposure limits. It is important, therefore, to delineate dermal absorption, and the metabolic pathways of EBDC fungicides and ETU for the development of biological monitoring methods. Moreover, an understanding of the effects of these fungicides on the thyroid is crucial for adequate risk assessment.
Descriptors (primary) Sweden; maneb; fungicides; ethylenethiourea; zineb; manzeb
Descriptors (secondary) threshold limit values; thyroid gland; sensitization; carcinogenic effects; criteria document; determination of exposure limits
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFinland; Sweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Agricultural chemicals