| Document ID (ISN) | 69237 |
| CIS number |
97-958 |
| ISBN(s) |
91-7045-298-9 |
| Year |
1995 |
| Convention or series no. |
Arbete och hälsa 1995:7
|
| Author(s) |
Beije B. |
| Title |
The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 117. Propene |
| Bibliographic information |
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1995. 38p. 115 ref. |
| Abstract |
Propene (propylene, PE) is an important industrial chemical which is also present as a contaminant in urban air and cigarette smoke. PE is metabolized to propylene oxide (PO), which binds to macromolecules, i.e. haemoglobin and DNA. PE is an asphyxiant. Human data are scarce. Inhalation of PE on a long-term basis gives rise to non-neoplastic toxic changes in the nasal cavity of rats, but not of mice. In male mice there is a higher incidence of chronic focal renal inflammation. In female mice there is a higher incidence of uterine endometrial stromal polyps and, to a lesser extent, haemangiosarcoma as well as haemangiosarcoma and haemangioma combined. There are limited data on the potential health hazard to humans due to PE exposure. However, as a metabolite, PO is carcinogenic in experimental animals. It is not possible at the present time to rule out PE as a human carcinogen. |
| Descriptors (primary) |
Sweden; propylene oxide; propylene |
| Descriptors (secondary) |
animal experiments; carcinogenic effects; determination of exposure limits |
| Document type |
F - Information notes, codes of practice, standards |
| Country / State or Province | Sweden |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Ethylene oxide
Aliphatic and alicyclic hydrocarbons
Ethers
|
