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Document ID (ISN)69233
CIS number 97-954
ISBN(s) 91-7045-284-9
Year 1994
Convention or series no. Arbete och hälsa 1994:36
Author(s) Sorsa M., Peltonen K.
Title The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 113. 1,3-Butadiene
Bibliographic information Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1994. 44p. 123 ref.
Abstract Criteria document to serve as a basis for a discussion on occupational exposure limits for 1,3-butadiene (BD), an important industrial chemical with an estimated annual world production exceeding 5 million tons. BD is used principally as a monomer for producing a wide range of polymers and copolymers, the largest single use being styrene-BD rubber for tyre products. BD also occurs as an environmental contaminant from traffic exhausts and tobacco smoke. Low exposure to BD is thus quite common. BD requires metabolic activation to reactive epoxides in order to bind to DNA and initiate events leading to mutations and cancer. Species differences in metabolism are therefore very relevant for risk assessment. The epoxide metabolites of BD are highly mutagenic in various assay systems. BD is a high-priority compound for risk assessments not only because of its widespread use but also due to its known toxicological properties. BD is practically nontoxic acutely, but it is a multiple-organ carcinogen in rats and (particularly) mice. Still, it is not clear whether BD, at the low human exposure levels occurring, can be shown to be carcinogenic, although epidemiological studies have revealed associations between occupational exposure to BD and excess mortality due to lymphatic and haematopoietic cancers.
Descriptors (primary) butadiene; Sweden
Descriptors (secondary) mutagenic effects; animal experiments; criteria document; carcinogenic effects; determination of exposure limits
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFinland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Aliphatic and alicyclic hydrocarbons