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Document ID (ISN)69029
CIS number 97-871
ISSN - Serial title 0040-6376 - Thorax
Year 1997
Convention or series no.
Author(s) Hnizdo E., Murray J., Klempman S.
Title Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners
Bibliographic information Mar. 1997, Vol.52, p.271-275. 19 ref.
Abstract In a cohort of 2260 South African gold miners, 78 cases of lung cancer were found during the follow-up period from 1970 to 1986. The risk of lung cancer was associated with tobacco smoking, cumulative dust exposure, duration of underground mining and silicosis. No association was found with uranium production. The results cannot be interpreted definitively in terms of causal association. High levels of exposure to silica dust on its own are important in the pathogenesis of lung cancer and silicosis is either coincidental or represents an increased risk. The risk is also increased in miners spending many hours underground, in which case high levels of silica dust exposure may be a surrogate for exposure to radon daughters.
Descriptors (primary) mineral dust; South Africa; radon daughters; silica; uranium mining; lung cancer; silicosis; risk factors; gold mining; smoking
Descriptors (secondary) cohort study
Document type D - Periodical articles
Country / State or ProvinceSouth Africa
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Pneumoconioses
Mining and quarrying
Radon
Inorganic substances
Smoking