ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)69027
CIS number 97-820
ISSN - Serial title 0040-6376 - Thorax
Year 1997
Convention or series no.
Author(s) Piitulainen E., Tornling G., Eriksson S.
Title Effect of age and occupational exposure to airway irritants on lung function in non-smoking individuals with α1 antitrypsin deficiency (PiZZ)
Bibliographic information Mar. 1997, Vol.52, p.244-248. Illus. 16 ref.
Abstract Severe α1-antitrypsin (AAT) deficiency (PiZZ) is associated with an increased risk of lung emphysema, especially in smokers. The aim of this study was to identify risk factors other than smoking for declining lung function. Lung function was studied in 225 self-reported never-smoking PiZZ subjects included in the Swedish AAT deficiency register. Lung function was poorer in men than in women. Among the PiZZ subjects, men reported occupational exposure to gases, fumes or dust more frequently than women. In those aged 50 or older, lung function declined. Asthmatic symptoms and occupational exposure to airway irritants appear to constitute additional risk factors for this condition.
Descriptors (primary) irritants; antitrypsin; risk factors; emphysema; respiratory function tests; smoking
Descriptors (secondary) report on investigation; Sweden
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Smoking
Diseases of the respiratory system (except for pneumoconiosis & similar)