|Document ID (ISN)||68912|
|ISSN - Serial title
||1250-3274 - Archives des maladies professionnelles et de médecine du travail
|Convention or series no.
||Lehucher-Michel M.P., Ait Amara Y., Botta A.
||Micronucleus assay on exfoliated urothelial cells: Effect of smoking and application to occupational biomonitoring
||Application du test de numération des micronoyaux aux cellules urothéliales exfoliées: effet du tabagisme et intérêt en médecine du travail [in French]|
||Oct. 1996, Vol.57, No.6, p.429-437. Illus. 82 ref.
||Exposure to genotoxic chemicals increases the incidence of bladder cancer. Smoking seems to have an additive effect on this cancer risk. Exfoliated bladder cell micronuclei assays may constitute a useful testing for genotoxic effects in populations with an increased risk of bladder cancer due to exposure to chemical substances. A micronucleus assay was applied to 73 healthy donors not occupationally exposed to genotoxic chemicals. Among the variables studied in 50 subjects presenting a number of analyzed urothelial cells at least equal to 1000, only smoking showed a significant effect on micronucleated cell rates (P = 0.007). Micronucleated cell levels in ex-smokers were slightly lower but not significantly different from that of smokers suggesting that smoking could generate clones of basal micronucleated cells in urothelial tissues. The importance of extending the micronucleus assay to target tissues is stressed.
||mutagenic effects; smoking; occupational medicine; genetic effects; exposure tests; exposure evaluation
||evaluation of technique
||D - Periodical articles
|Country / State or Province||France|
||Medicine, hygiene and first aid
|Broad subject area(s)
||Occupational medicine, epidemiology
||Antifertility and prenatal effects
Genetic factors in reaction to exposures