| Document ID (ISN) | 68775 |
| CIS number |
97-552 |
| ISSN - Serial title |
1219-1221 - Central European Journal of Occupational and Environmental Medicine |
| Year |
1996 |
| Convention or series no. |
|
| Author(s) |
Jakab M.G., Major J., Tompa A. |
| Title |
HPRT mutation frequencies in control human populations in Hungary |
| Bibliographic information |
1996, Vol.2, No.4, p.317-328. 47 ref. |
| Abstract |
Mutation frequencies in the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) genes in human peripheral blood lymphocytes were determined in two groups of donors: 101 healthy persons living and working in non-industrialized areas (historical controls), and 87 persons working in chemical industrial estates with no known exposure to genotoxic materials (industrial controls). The distribution of the variant frequency of HPRT point mutations showed no statistical difference between the two groups. Results are analyzed with respect to age, sex, smoking and drinking habits, seasonal factors and residential area. Implications for genotoxicological monitoring are discussed. |
| Descriptors (primary) |
mutagenic effects; Hungary; chemical industry |
| Descriptors (secondary) |
smoking; epidemiologic study; age-linked differences; neighbourhood populations; case-control study |
| Document type |
D - Periodical articles |
| Country / State or Province | Hungary |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
