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CISDOC database

Document ID (ISN)68755
CIS number 97-481
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1994
Convention or series no.
Author(s) Caporaso N.E., Landi M.T.
Title Molecular epidemiology: A new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies
Bibliographic information Jan.-Feb. 1994, Vol.85, No.1, p.68-77. 45 ref.
Abstract Epidemiologic evidence for genetic susceptibility factors in tobacco-related cancer is suggestive but not determinant. Variability in results depends on: assay misclassification, non-correspondence of phenotype/genotype in certain subjects, disease heterogeneity, exposure variation, ethnic and racial variation. Future studies should concentrate on the presence of multiple genetic markers. The observation that the tobacco-cancer association is weaker for adenocarcinoma than for the other lung cancers suggests some interaction of the genetic trait with exposure to tobacco smoking.
Descriptors (primary) smoking; individual susceptibility; genetic effects; lung cancer
Descriptors (secondary) carcinogenic effects; epidemiology
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Diseases of the respiratory system (except for pneumoconiosis & similar)